GLP-1 medications are transforming the way we approach weight management and metabolic health. But as powerful as they are, these therapies can also shift how your body absorbs essential nutrients — and that can affect more than your metabolism. It can also influence your hormones, energy levels, and overall vitality.
The Role of Delayed Gastric Emptying
One of the ways GLP-1s work is by slowing down how quickly food moves through your digestive system, through a process called delayed gastric emptying. This helps regulate blood sugar and appetite — making GLP-1s so effective for weight loss and metabolic control.
But there’s a slight downside: when food and nutrients are digested more slowly or not completely, it’s harder for the protein named Intrinsic Factor (IF) to bind to B12 in your food, which reduces the amount of B12 absorbed into the small intestine.
Why B12 Matters for Hormones and Energy
Vitamin B12 isn’t just about energy (though it plays a big role there). It’s also essential for:
Healthy red blood cells → preventing fatigue and anemia
Nervous system health → supporting focus and mood
Hormone balance → helping with estrogen and progesterone metabolism
Over time, this nutrient gap can show up as low energy or brain fog, mood fluctuations, hormonal shifts, and hair shedding.
How GLP-1s and B12 Work Together
Pairing GLP-1 therapy with B12 supplementation helps counterbalance absorption challenges and keeps your body supported as you lose weight and rebalance your metabolism.
For many patients, this means:
More stable energy
Support for healthy hormones
Better mood and focus
Protection against nutrient deficiencies
A Direct Solution: B12 Injections
Stay supported while you’re on your health journey. Our GLP-1s can include B12 in the vial so you receive supplemental B12 during your weekly GLP-1 injection and if you’re not using that formulation of GLP-1 + B12, we also have standalone B12 injections. Regardless of which you’re using, you’ll receive the nutrients your body needs to stay balanced, energized, and hormonally supported.
Whether you’re using GLP-1 therapy, managing hormone changes with age, or just want to boost your energy and focus, B12 injections may be the missing link.