Low-Dose Naltrexone (LDN)

Longevity

Naltrexone

Immune-Modulating Support for Inflammation, Chronic Pain, and Autoimmunity

Low-Dose Naltrexone (LDN) is a compounded, low-dose version of the FDA-approved medication naltrexone, used off-label to support immune regulation, reduce inflammation, and help manage chronic pain conditions. LDN is widely used in functional and integrative medicine to support patients with autoimmune disorders, fibromyalgia, long COVID, chronic fatigue, and inflammatory conditions.

Understanding Low-Dose Naltrexone (LDN)

At standard doses (50mg), naltrexone is approved for treating opioid and alcohol dependence. At much lower doses (typically 0.5 mg to 4.5 mg), LDN works differently—modulating immune function and reducing inflammation via temporary endorphin receptor blockade.

This brief receptor interruption prompts a rebound effect, increasing the body’s natural production of endorphins and opioid growth factors, which may help balance immune activity, reduce pain, and improve overall wellness.

LDN is not habit-forming, does not cause euphoria or sedation, and is generally well tolerated when titrated appropriately.

Potential Benefits

Supports Immune Regulation: May help calm overactive immune responses in autoimmune conditions like Hashimoto’s, MS, Crohn’s, and RA.
Reduces Inflammation: LDN has shown promise in reducing systemic inflammation and related symptoms.
Manages Chronic Pain: May improve pain tolerance and reduce central sensitivity in conditions like fibromyalgia and chronic fatigue syndrome.
Improves Mood & Sleep: Some users report enhanced emotional stability and better sleep quality.
Non-Habit Forming: No risk of addiction or physical dependence.

Please note: Benefits may vary, and evidence for many use cases is still emerging. LDN is not FDA-approved for these indications.

Key Ingredients

Naltrexone (Low Dose):
Typically compounded between 0.5 mg and 4.5 mg per capsule, depending on your provider’s recommendations.
Base Fillers (may include):
Microcrystalline cellulose or other non-reactive excipients used for capsule formulation. Gluten-free, dye-free, and preservative-free options are often available.

LDN is a compounded medication and is custom-formulated by a licensed compounding pharmacy based on your needs.

Warnings & Information

Prescription Required:
LDN must be prescribed by a licensed healthcare provider and filled by a reputable compounding pharmacy.
Start Low & Titrate Slowly:
LDN is typically started at a low dose (e.g., 0.5 mg) and increased gradually to reduce the risk of side effects.
Possible Side Effects:
Most common: vivid dreams or sleep disturbances (usually temporary). Others may include headaches, nausea, or mild agitation.
Drug Interactions:
LDN should not be used in patients actively taking opioid medications (painkillers, cough suppressants), as it may block their effects.
Pregnancy & Breastfeeding:
LDN should only be used during pregnancy or breastfeeding under close medical supervision.
Monitoring Recommended:
Providers may monitor your response with periodic check-ins or lab work to assess efficacy and tolerance.