Compounded Cream
Estradiol Cream is a prescription topical estrogen therapy used to treat symptoms of vaginal atrophy, dryness, itching, burning, and painful intercourse commonly associated with menopause, perimenopause, or surgical hormone loss. This low-dose cream delivers estradiol, the primary form of estrogen in the body, directly to vaginal tissues—providing localized relief with minimal systemic absorption.
Applied regularly, estradiol cream helps restore comfort, elasticity, and pH balance, improving both sexual and urinary health.
As estrogen levels decline during menopause or due to certain medical treatments, vaginal tissues can become thinner, drier, and more fragile, leading to discomfort and increased risk of urinary symptoms or infections. Estradiol cream works by replenishing estrogen locally, helping to:
Restore vaginal moisture and elasticity
Improve tissue thickness and blood flow
Reduce pain with intimacy
Support urinary tract health and reduce irritation
Unlike systemic hormone therapy, estradiol cream is applied directly to the vaginal area, offering targeted relief with a lower overall hormone exposure.
Relieves Vaginal Dryness & Discomfort
Hydrates and rejuvenates vaginal tissues for greater daily comfort.
Improves Sexual Health
Reduces painful intercourse (dyspareunia) and enhances natural lubrication.
Supports Urinary Function
May reduce urgency, frequency, and irritation caused by tissue thinning or pH imbalance.
Localized Hormone Delivery
Targets the area that needs it most, with minimal impact on the rest of the body.
Safe for Long-Term Use Under Medical Supervision
FDA-approved for postmenopausal women with appropriate monitoring.
Formulated in a cream base for topical application. Dose and frequency are determined by your provider based on your needs and symptom severity.
Prescription Required
Estradiol cream must be prescribed and used under the supervision of a licensed medical provider.
Possible Side Effects
May include mild vaginal irritation, discharge, or breast tenderness. These usually resolve with continued use or dose adjustment.
Not for Use in Certain Conditions
Contraindicated in individuals with a history of estrogen-sensitive cancers, unexplained vaginal bleeding, or active blood clots.
Monitoring Recommended
Periodic exams and check-ins with your provider are important to ensure safety and effectiveness.
Pregnancy and Breastfeeding
Not recommended during pregnancy or while nursing. Always disclose your full medical history to your provider.
