Bupropion / Naltrexone HCl
A compounded oral medication prescribed after a provider evaluation as part of a medically supervised weight program. It is not FDA approved.
Compounded drugs are not FDA approved. FDA does not review compounded drugs for safety, effectiveness, or quality before marketing.
See it before your first visit
Photographs of the medication as dispensed.
What it is
Bupropion / Naltrexone HCl is a compounded oral medication that combines bupropion and naltrexone hydrochloride. It is prescribed by a licensed provider as part of a medically supervised weight program.
It is a compounded medication. It is not FDA approved, and the FDA has not evaluated it for safety, effectiveness, or quality.
How it works
Bupropion and naltrexone act on brain pathways involved in appetite and reward. Your provider will explain the dose, how it is increased over time, and when to take it.
What to expect
Many prescribers start at a low dose and increase it gradually. Nausea, headache, constipation, and trouble sleeping are common early on. Your provider will schedule follow-ups to review how you are doing. Results vary and no outcome is guaranteed.
Who it is for
This medication is prescribed by a licensed provider after an evaluation. It is not appropriate for everyone. Tell your provider if you have a seizure disorder, an eating disorder, uncontrolled high blood pressure, liver or kidney disease, or a history of mental health conditions, and if you use opioid medications or are pregnant or breastfeeding.
Side effects
Common side effects include nausea, constipation, headache, dizziness, dry mouth, and trouble sleeping. Serious effects can include seizures, increased blood pressure, and changes in mood or behavior. Contact your provider right away if you have new or worsening mood changes, agitation, or thoughts of self-harm.
Read this before you start
Compounded drugs are not FDA approved. FDA does not review compounded drugs for safety, effectiveness, or quality before marketing.
Medication availability, formulation, packaging and pharmacy fulfillment vary based on the patient's prescription and location.
Compounded medication. This medication is compounded by a pharmacy for an individual patient. It is not FDA approved, and the FDA has not evaluated it for safety, effectiveness, or quality.
Boxed warning, suicidal thoughts and behavior. Bupropion, an antidepressant ingredient, carries a boxed warning for increased risk of suicidal thoughts and behavior in children, adolescents, and young adults. Report any new or worsening mood or behavior changes to your provider immediately.
Seizure risk. Do not use if you have a seizure disorder or are going through abrupt alcohol or sedative withdrawal.
Opioids. Naltrexone blocks opioid medications and can trigger withdrawal. Tell your provider about any opioid use.
Blood pressure. This medication can raise blood pressure. Your provider may monitor it.
Tell your provider about all medications you take, including antidepressants and MAOIs.
This page is for general information and is not medical advice.
Common questions
Is Bupropion / Naltrexone FDA approved?
Not as a compounded medication. The FDA has not evaluated compounded versions for safety, effectiveness, or quality.
How is it taken?
It is taken by mouth as directed by your prescriber and pharmacy label.
Who should not take it?
People with a seizure disorder, an eating disorder, or opioid use, among others. Your provider will review your history.
What should I watch for?
Report mood or behavior changes, seizures, or a sharp rise in blood pressure right away.
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