Tretinoin
Prescription tretinoin is an FDA-approved topical retinoid for acne. Certain strengths are also approved to help with fine facial wrinkles as part of a full skin care program. A licensed provider decides if it is right for you.
Compounded drugs are not FDA approved. FDA does not review compounded drugs for safety, effectiveness, or quality before marketing.
See it before your first visit
Photographs of the medication as dispensed.
What it is
Tretinoin is a prescription retinoid, a form of vitamin A, applied to the skin. It is one of the most studied topical skin care medications, and the FDA has approved tretinoin products for specific uses.
Tretinoin creams and gels are FDA approved to treat acne vulgaris. Certain tretinoin cream strengths are also FDA approved as an add-on to a skin care and sun protection program to help with fine facial wrinkles, uneven dark spots, and rough skin. Which uses apply depends on the exact product and strength your provider prescribes.
Tretinoin requires a prescription. A licensed provider will review your skin, your history, and your goals before prescribing it.
How it works
Tretinoin speeds up skin cell turnover and helps keep pores from clogging, which is why it is used for acne. For fine wrinkles, rough texture, and uneven pigmentation, it works over time with daily sun protection and a gentle skin care routine.
What to expect
Most prescribers start with a low strength a few nights a week and build up as your skin adjusts. A common routine is to wash your face, wait until it is fully dry, apply a pea-sized amount to the whole face in the evening, and use moisturizer and sunscreen every day.
Dryness, redness, and peeling are common in the first weeks. Acne can look worse before it improves. Many people need several weeks to months of steady use to see change, and results vary. Your provider will check in on your progress and adjust the plan. No outcome is guaranteed.
Who it is for
Tretinoin may be an option for adults with acne, or with fine wrinkles, rough texture, and uneven tone who are ready for a daily routine that includes sunscreen. It is not right for everyone.
Tell your provider if you are pregnant, planning to become pregnant, or breastfeeding, or if you have eczema, a history of skin cancer, or very sensitive or sunburned skin. Also share every skin care product and medication you use, especially other acne treatments, exfoliants, and medicines that make skin sensitive to the sun.
Side effects
Common side effects include redness, dryness, peeling, burning, stinging, and itching. Skin can become more sensitive to sun, wind, and cold. Temporary darkening or lightening of the skin can also occur.
Stop use and contact your provider if you have severe irritation, swelling, blistering, or signs of an allergic reaction.
Read this before you start
Compounded drugs are not FDA approved. FDA does not review compounded drugs for safety, effectiveness, or quality before marketing.
Medication availability, formulation, packaging and pharmacy fulfillment vary based on the patient's prescription and location.
FDA status. Tretinoin is FDA approved. Tretinoin creams and gels are approved to treat acne vulgaris. Certain tretinoin cream strengths are also approved as an adjunct for fine facial wrinkles, mottled dark spots, and rough skin, together with a skin care and sun protection program. Approved uses vary by product and strength. Your provider will tell you which product you are prescribed.
Pregnancy. Do not use tretinoin if you are pregnant or planning to become pregnant. Tell your provider right away if you become pregnant while using it.
Sun exposure. Tretinoin can make skin burn more easily. Avoid sunlamps and tanning beds, limit sun exposure, wear broad-spectrum sunscreen daily, and wear protective clothing.
Do not apply to cuts, scrapes, eczema, or sunburned skin. Keep away from eyes, the corners of the nose, mouth, and mucous membranes. Use caution with other products that dry or irritate the skin, such as harsh cleansers, strong exfoliants, and products with alcohol.
Use as directed. Using more than directed will not speed up results and can increase irritation. For external use only.
This page is for general information and is not medical advice.
Common questions
Is tretinoin FDA approved?
Yes. Prescription tretinoin creams and gels are FDA approved to treat acne vulgaris. Certain tretinoin cream strengths are also FDA approved as an adjunct for fine facial wrinkles, mottled dark spots, and rough skin, together with a skin care and sun protection program.
Do I need a prescription for tretinoin?
Yes. Tretinoin is a prescription medication. A licensed provider must evaluate you before prescribing it.
How long does tretinoin take to work?
It varies. Many people need several weeks to months of consistent use before they see change, and skin can be irritated or look worse at first. Your provider will guide your routine.
How do I apply tretinoin?
Follow your label and provider directions. A typical routine is to apply a pea-sized amount to clean, fully dry skin in the evening, then use moisturizer, and use sunscreen every morning.
What are the common side effects of tretinoin?
Redness, dryness, peeling, burning, and sun sensitivity are the most common. They often ease as your skin adjusts.
Can I use tretinoin if I am pregnant or breastfeeding?
Do not use tretinoin if you are pregnant or planning to become pregnant. Talk to your provider if you are breastfeeding.
Can I use tretinoin with other skin care products?
Ask your provider. Exfoliants, scrubs, and other acne treatments can increase irritation when combined with tretinoin.
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